Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL SCREENING OF AZO COMPOUNDS CONTAINING TYROSINE MOIETY

Ramesh F. Pagariya* and Nandkishor S. Thakare

ABSTRACT

Synthesis of most azo compounds involves diazotization of a primary aromatic amine, followed by coupling with one or more nucleophiles. Thus, benzoic, phenolic, salicylic and naphtholic compounds acts as nucleophiles and undergoes coupling reactions. In this study, a series of azo compounds were synthesized with excellent yields via the diazotization of different aromatic amines followed by coupling with Tyrosine, which is a phenol as well as amino acid. These compounds were characterized by elemental analysis, IR, 1HNMR and MASS spectroscopic techniques. The synthesized compounds have been tested in vitro against human pathogens in order to assess their antibacterial properties using disk diffusion method. The compounds analysed for its antibacterial action showed moderate to extraordinary inhibitory effect at most of the concentrations against all the tested pathogens.

Keywords: Tyrosine, Azo compounds, Antibacterial Activity, Human pathogens.