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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

PHYTOCHEMICAL AND TOXICOLOGICAL STUDIES OF METHANOL EXTRACT OF AGAVE SISALANA (AGAVECEAE)

*U. M. Jajere., C. Hammuel, M. Mohammed, P.O. Okibe, E.O. Ali., A. Abubakar, N. Aliyu

ABSTRACT

Phytochemical and toxicological studies of the methanol extract of Agave sisalana (Agaveceae) were evaluated. The plant leaf is exploited in folkloric medicine for the treatment of antimicrobial infections such as bacterial conjuctivities, scabies, pesticidal, insecticidal properties were reported from the plant. Standard methods were adopted for phytochemical screening and toxicological study. Phytochemically, the leaf contains alkaloids, flavonoids, saponins (steroids and triterpenes) and cardiac glycosides. Toxicity study of the leaf revealed the median lethal dose (LD50) of 282.84mg/k as moderately toxic. The plant leaf is moderately toxic and could be used in the herbal therapeutic purposes with regulation and quality control process.

Keywords: Phytochemical, Toxicological, Agave sisalana, Agaveceae, Median Lethal Dose.

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