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IN VITRO ANTIOXIDANT ACTIVITY OF 9-SUBSTITUTED DERIVATIVES OF 9-PHENYL-5,9-DIHYDROPYRIMIDO[4,5-d][1,2,4] TRIAZOLO[1,5-a]PYRIMIDINE-6,8(1H,7H)-DIONE
Vijay N. Bhosale*, Gopinath S. Khansole and Jaman A. Angulwar
ABSTRACT A green, efficient procedure has been developed for the synthesis of 9-substituted derivatives of 9-phenyl-5,9-dihydropyrimido[4,5-d] [1,2,4] triazolo[1,5-a] pyrimidine-6,8(1H,7H)-dione from a multicomponent one pot three molecule condensation of 3-amino-1H-1,2-4-triazole, Barbituric acid and tetrabutyl ammonium hydrogen sulphate (TBAHS) in water-ethanol with different substituted aromatic aldehydes were screened for their In Vitro Antioxidant activity. Keywords: 3-amino-1H-1,2-4-triazole, Barbituric acid, Aromatic Aldehyde , TBAHS, MCR’s. [Download Article] [Download Certifiate] |