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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

DEVELOPED & VALIDATED A NEW SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF ALLOPURINOL IN TABLET DOSAGE FORM

Dr. Parminder Nain*, Rajiv Kumar and Dr. Jaspreet Kaur

ABSTRACT

The aim of this research was to develop and validate a simple, sensitive, accurate and rapid spectrophotometric method for estimation of allopurinol. Allopurinol is a structural analogue of hypoxanthine and acts to inhibit xanthine oxidase for treatment of hyperuricaemia and gout. Allopurinol was estimated at 250 nm and the percentage recovery was found to be 100.4 ± 0.65. The method was tested and validated for various parameters according to the ICH guidelines. The proposed methods were accurate, precise, reproducible and economical for the routine analysis of allopurinol in bulk drug and in formulation. The LOD and LOQ were 0.73 and 2.2μg/ml respectively. The method was applied successfully for the estimation of allopurinol in tablet dosage form without the interference of common excipients.

Keywords: Allopurinol, Gout, ICH, UV-Spectrophotometry, Validation.

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