Abstract

SPERMATOTOXIC EFFECT OF BISPHENOL A AND ITS AMELIORATION USING QUERCETIN

Sanman Samova, Hetal Doctor and R. J. Verma*

ABSTRACT

The present investigation was an attempt to evaluate the spermatotoxic effect of BPA and its amelioration by quercetin. For this inbred Swiss strain male albino mice were orally administered with different doses of BPA (80, 120 and 240 mg/kg body weight/day) for 45 Days. On completion of treatment, animals were sacrificed, epididymis were isolated and used for evaluation of sperm parameters. The results revealed that oral administration of BPA for 45 days caused, significant, dose-dependent changes in sperm functional parameters such as sperm count, motility, viability and morphology. Oral administration of quercetin (30, 60 and 90 mg/kg body weight/day) along with high dose of BPA (240 mg/kg body weight/day) for 45 dayscaused significant (p<0.05) amelioration in all sperm parameters as compared to high dose BPA alone treated group. The effect was dose-dependent. This amelioration in spermatotoxic effect might be due to antioxidant property of quercetin.

Keywords: Bisphenol A (BPA), Quercetin, Spermatotoxicity, Viability, Motility, Sperm count, Morphological abnormalities.