Abstract

PHARMACEUTICAL DEVELOPMENT AND DOSAGE FORM MODIFICATION OF LEPA GUTI; AN AYURVEDIC TOPICAL FORMULATION.

*Abhay Jayprakash Gandhi, Shikha Sharma, Bhakti Sitapara, Pankaj Goriya, Prashant Bedarkar and B. j. Patgiri

ABSTRACT

Various pharmaceutical aspects of topical formulation are judiciously applied in Ayurvedic therpeutics. Lepa Guti is one of the very unique, rare and important formulation among classical formulations.The lepa guti is used traditionally for rheumatic complaints like local inflammation,local pain, joint pain, muscular skeletal pain. Classical mode of aplication of lepa guti involves preparation of mixture in water and heating at the time of application, which might be a hurdle in assurance of controlled and desired clinical effects. To overcome this and in view of palatability, standard operating procedure of its application, dosage form of lepa guti was modified to gel, ointment and cream. The crude material was procured from the Pharmacy, Gujarat Ayurved university and the excipients were bought from Manakarnika Ayushadhalaya, Pune, India. Pharmaceutical study was done at the department of rasa shastra and bhaishjya kalpana and Analysis of formulations was done in accordance of standard strategies. Gel form was observed as superior over lepa guti, cream and ointment in terms of spreadibility,percentage yield, ease in method of preparation. All modified dosage forms were found to be more palatable than classical lepa guti. Comprative pharmacological and or clinical studies will only proove the superiority of modified dosage forms.

Keywords: Lepa Guti, Topical Application, Rheumatoid Arthritis, Joint Pain.