Abstract

PHOSPHOLIPID: AS NOVEL EXCIPIENT

Palve Shivprasad P*, Warad Shubhangi, Solunke Rahul, Somwanshi Bhagwat, Deshmukh Vikrant, Jagdale Ganesh

ABSTRACT

Phospholipids become increase important as formulation excipients and as active ingredients, the present article summarizes particular features of commonly use phospholipids and their application spectrum within oral drugformulation and elucidates current strategies to improve bioavailability and disposition of orally administered drugs. The phospholipid molecule makes up cell membranes. It is ultimately responsible for controlling what goes in/out of the cell, maintaining form and structure and many other things. Advantages of phospholipids formulations not only comprise enhanced bioavailability of drugs with low aqueous solubility or low membranepenetration potential, but also improvement or alteration ofuptake and release of drugs protection of sensitive active agents from degradation in the gastrointestinal tract, reduction of gastrointestinal side effects of non-steroidal anti-inflammatorydrugs and even masking of bitter taste of orally applied drugs.Technological strategies to achieve these effects are highly diverseand offer various possibilities of liquid, semi-liquid and solid lipid basedformulations for drug delivery optimization.

Keywords: Phospholipid, Sources, enzymatic Hydrolysis, Novel Excipient, Drug delivery.