Abstract

REVIEW ON: RECENT ADVANCEMENT IN ORAL CONTROLLED RELEASE TECHNOLOGY

Puja M. Jamode*, Subhash Deshmane, Swapnil Bharad, Radhika Rathi

ABSTRACT

Pharmaceutical invention and research are increasingly focusing on delivery systems which enhance desirable therapeutic objectives while minimizing side effects. Pulsatile drug delivery system is defined as the rapid and transient release of certain amount of drug molecules within a short time period immediately after a predetermined off-release period, i.e., lag time. Pulsatile drug delivery aims to release drug on programmed pattern i.e. at appropriate time and at appropriate site of action. Pulsatile systems are gaining a lot of interest as the drug is released completely after defined lag time. Currently pharmaceutical company focused on developing and commercializing pulsatile drug products that fulfill medical needs in the treatment of various diseases. Recently develop various technologies that presents in this review are Accu-Break™ Technology, CODAS™ Technology, Geoclock®, Geomatrix™ Technology, IPDAS® Technology, PRODAS® Technology, Diffucaps® Technology.

Keywords: Pulsatile delivery, controlled release, immediate release, flexibility.