Abstract

LIPOSOME: EMERGING TRENDS IN TRANSDERMAL DRUG DELIVERY

Naveen Thakur*, Choudhary Abhilash, Kumar Vivek, Bharti Nitan, Bhandari Neeraj

ABSTRACT

Liposome is acceptable and superior carrier and has ability to encapsulate hydrophilic and lipophilic drugs and protect them from degradation. Liposomes are vesicles having concentric phospholipids bilayer molecules from low molecular weight to higher molecular weight have been incorporated in liposomes. The water soluble compounds/drugs are present in aqueous compartments while lipid soluble compound/drugs and amphiphilic compounds/ drugs insert themselves in phospholipids bilayers. Liposome containing drugs can be administrated by many routes (intervenous, oral, inhalation, local application, ocular) and these can be used for treatment of various diseases. Liposomes are biocompatible, completely biodegradable, nontoxic, and non-immunogenic. Liposomes are prepared by using various methods hydration, ethanol injection method, ether injection method, Sonication method, micro-emulsion method. The different application of liposomes is use for treatment of infection, anti-cancer, vaccination, for human therapy and gene delivery system.

Keywords: Intervenous, oral, inhalation, local application, ocular.