Abstract

MORPHOLOGICAL CHANGES OF THYROID GLAND UNDER EXPERIMENTAL HYPOTHYROIDISM, DEPENDING ON ACETYLATION PHENOTYPE

Khamid Y. Karimov*, Saidamir A. Saidov, Asliddin K. Ahmadjonuv#

ABSTRACT

Background. The study of morphological changes in the thyroid gland can contribute to a better understanding of the pathophysiological processes occurring in the body and in the thyroid gland in hypothyroidism with different phenotypes of acetylation (metabolic types). Purpose. To study the morphology of the thyroid gland and their correlation with changes of hormonal status in experimental hypothyroidism at different acetylation phenotypes. Material and Methods. We utilized 200 rats weighing 180-220g., we studied the metabolic rate with the help of an elimination test sulfadimezin, in which they were divided into 2 main groups. There were α- "slow" (low resistant) and β- "fast" metabolizer (distribution) according to the type of acetylation. In both groups simulated experimental hypothyroidism by introducing Mercasolyl dose of 5 mg, for 21 days. The levels of gland substances were examined. The investigated parameters were studied in α and β subgroups. Results. The levels of total triiodothyronine on the 1st week, free triiodothyronine on the 1st and 3rd week, free thyroxine 4th hour and 1st week followed-up, demonstrating the impact of acetylation rate metabolizing enzymes in thyroid status of the organism. The concentration of TSH at the 4th hour, 1st, 2nd and 3rd weeks in the groups with β-acetylation phenotype, 1.6, 1,74, to 1.44 and 1.67 times, respectively, significantly higher compared to subgroups with α-acetylation phenotype. The level of TSH was 1.6 Iα significantly higher than in the subgroup Iβ. Conclusion. Differentiation by acetylation phenotypes in experimental hypothyroidism allows detecting differences not only in the functional state of the thyroid gland but also in its morphological aspect, correlating and complementing each other. For "fast" β-acetylation phenotype (with the high rate of metabolism (HM) are characterized by changes in the functional state of the thyroid gland correlate with deeper morphological changes, leading to the predominance of the processes of hardening.

Keywords: thyroid gland; acetylation; sulfadimezin; mercasolyl; triiodothyronine; TSH.