Abstract

PHARMACOECONOMIC EVALUATION OF ANTIBIOTICS IN URINARY TRACT INFECTION AT TERTIARY CARE HOSPITAL

R. Sivasakthi*, Johana Joseph, Anjali Elsa Sam and W. D. Sam Solomon

ABSTRACT

The Prospective observational study with 50 UTI patients conducted for 6 months period with aimed to analyzed the therapeutic effectiveness and economic burden of UTI female patients due to the overall incidence of urinary tract infection increases substantially in this population; with the majority of infections being asymptomatic. The rate of infection increases further for elderly persons who are in nursing homes. The increase is probably the result of a number of factors including obstruction from prostatic hypertrophy in males, poor bladder emptying as a result of prolapse in females, fecal incontinence in dementia patients, neuromuscular diseases-such as stroke and increased urinary catheterization. And it results that urinary tract infection has a negative impact on the functional capacity and QOL and also impose socioeconomic burden on the patients. The functional capacity and QOL impact score was high before antibiotic administration, whereas after antibiotic administration, the impact score was reduced significantly. Pharmacoeconomics analysis of the administered antibiotics were analyzed and the mostly prescribed antibiotic is cefoperazone+sulbactam (36%) at a cost of Rs.400 increase the effectiveness by 35% of patients. And the study concludes that that amikacin as the effective and cost effective antibiotic and antibiotics are effective in increasing the functional capacity and Quality of life of the patients.

Keywords: Urinary tract infections, Antibiotic Resistance, Pharmacoeconomics, Catheter.