Abstract

IMMEDIATE RELEASE DRUG DELIVERY SYSTEM: AN OVERVIEW

Rahul L. Waman*, Salunkhe K.S., Chaudhari S.R., Gade A.V. and Kakad S.B.

ABSTRACT

Tablet is the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; however in many cases immediate onset of action is required than conventional therapy. To overcome these drawbacks, immediate release pharmaceutical dosage form has emerged as alternative oral dosage forms. There are novel types of dosage forms that act very quickly after adminstration. The basic approach used in development tablets is the use of superdisintegrants like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab), Polyvinyl pyrrolidone (Polyplasdone) etc. which provide instantaneous disintegration of tablet after administration. Immediate release liquid dosage forms and parenteral dosage form have also been introduced for treating patients. dosage form can be suspensions with typical dispersion agents like hydroxypropyl methylcellulose, (dioctylsulfosuccinate) etc. The development of immediate release therapy also provides an opportunity for a line extension in the marketplace, A wide range of drugs (e.g., Antidiabetic, neuroleptics, cardiovascular drugs, analgesics, antihistamines and drugs can be considered candidates for this dosage form.

Keywords: immediate release, superdisintegrants, compactness.