Abstract

EVALUATION OF QUERCUS INFECTORIA (GALLS) EXTRACTS FOR THE MANAGEMENT OF DIABETES

Sumit Kumar* and Deepshikha Dubey

ABSTRACT

The objective of this study was to investigate the Antidiabetic activity of galls of Quercus infectoria in rats. The antidiabetic activity of methanolic & aqueous extract was evaluated in Glucose tolerance test & Sucrose tolerance Test model in wistar rats. The galls methanolic & aqueous extract was prepared by maceration extraction process using methanol & water as solvent. Phytochemical analysis & acute oral toxicity were carried out using standard methods. The preliminary phytochemical screening of Quercus infectoria revealed the presence of sterols, protein, alkaloid, tannins, phenolic compounds & flavonoids. The methanolic & aqueous extract at a concentration of 500 mg/kg exhibit a blood glucose lowering effect on diabetes models & was compared with standard drug Acarbose. The percentage reduction of blood glucose level within 4 hr in Glucose tolerance test for methanolic extract & aqueous extract was 18.5% & 2.58% respectively and for Sucrose tolerance test percentage reduction of blood glucose level within 4 hr was 16.92% & 9.7% respectively. Among the two extracts studied methanolic extract 500 mg/kg body weight was found to be optimum for significant blood glucose lowering.

Keywords: Antidiabetic activity, acarbose, Glucose, Quercus infectoria.