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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF KETOROLAC TROMETHAMINE IN BULK DRUG

Rupinder Kaur*, Sukhdev Singh, Aaliya Hassan, Sunny Jalhan and Upendra K Jain

ABSTRACT

The aim of the study was to develop and validate robust, accurate and precise UV spectrophotometric method for determination of Ketorolac Tromethamine. The developed method was validated as per International Conference on Harmonization (ICH) guidelines. The spectrophotometric detection was carried out at an absorption maximum of 322 nm using water as solvent. The method was validated for specificity, linearity, accuracy, precision, robustness and ruggedness. The detector response for the Ketorolac Tromethamine was linear over the selected concentration range 2 to 14 μg/ml with a correlation coefficient of 0.998. The accuracy was between 98 to 101%. The LOD and LOQ are 0.031 and 0.00967 μg/ml respectively.

Keywords: Ketorolac Tromethamine, UV spectrophotometry, Validation.

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