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COMPARATIVE STUDY OF ATORVASTATIN 10MG WITH EZETIMIBE 10MG COMBINATION VERSUS ATORVASTATIN 80MG FOR LIPID METABOLISM AND PLEIOTROPIC VASCULAR INFLAMMATORY BIOMARKERS IN DIABETES MELLITUS PATIENTS.
Gune Aryan Rahul*, Meeta Burande, Gune Anita R., Gune Rahul P.,
ABSTRACT Patients with diabetes have an overall increased risk of cardiovascular disease. Beneficial effect of statin may be due to pleotropic effect when used along with ezetimibe. Aims and objectives of this study were to study the efficacy and safety of 80mg atorvastatin with 10mg atorvastatin and 10mg ezetamibe combination in reduction of lipid biomarkers in uncontrolled dyslipidemia in diabetes patients. The study was conducted after the approval of ICMR-STS committee and institutional ethical committee. 200 Patients were screened out of which 72 volunteers were consulted. 35 of which were selected on basis of inclusion and exclusion criteria. Volunteers were randomised to any of the 2 groups. In-group A, they received atorvastatin 80mg at bedtime for 1 month. In-group B they received atorvastatin 10mg and ezetamibe 10mg at bedtime for 1 month. Our study concludes that combination of Statin and ezetimibe is equipotent to maximum dose of statin at reducing LDL-C but combination shows more reduction in the c-reactive protein levels, suggestive of lesser chances of inflammation. Our results are favourable, further studies may be conducted for evaluation in long term efficacy including reduction in common carotid intima thickness reduction, progression of atherosclerosis as well as evaluation of other specific and extensive vascular markers. Keywords: Pleotropic inflammatory biomarker, atorvastatin, ezetamibe. [Download Article] [Download Certifiate] |