Abstract

EXPERIMENTAL STUDY ON IMMUNOMODULATORY ACTIVITY OF NAGBALA (SIDA HUMILIS CAV)

Dr. Shobha Khilari (Asso. Professor), Dr. Pallavi Anand Sathe* (MD Scholar)

ABSTRACT

Background and aim: Nagbala is mentioned as Rasayana drug and used in treatment of Kasa, Raktpitta Kshata and Kshaya in classical text. Three plant species are considered as Nagbala by different scholars, Sida spinosa L., Sida humilis cav. and Grewia hirsuta Vahl. Out of these Sida humilis is selected as Nagbala to evaluate its immunomodulatory activity. So, the present study was aimed at evaluating the immunomodulatory activity of Nagbala (Sida humilis Cav.) roots by using Choorna and Kwath of roots in DTH model. Methodology: Collection, identification and authentication of drug was done. Pharmacognostical study containing organoleptic, microscopic and physical has been performed. In experimental study Immunomodulatory activity was performed on Swiss Albino Mice DTH model, using choorna and Kwath of Drug orally. Results: Study of Immunomodulatory activity defined that Nagbala (Sida humilis Cav.) shows immunomodulatory activity by showing immune response to SRBCs by increasing paw volume in mice.immunomodulatory activity of drug was compared to disease control group. Interpretation: By the experimental study it is cleared that Nagbala (Sida humilis Cav.) shows immunomodulatory activity but Kwath shows more immune response than powder of Nagbala roots.

Keywords: Nagbala, Sida humilis Cav., immunomodulatory activity.