Abstract

CORRELATION OF SERUM CHOLINESTERASE AND SERUM CREATINE PHOSPHOKINASE ENZYMES WITH THE SEVERITY AND OUTCOME OF ACUTE ORGANOPHOSPHORUS POISONING: STUDY IN RURAL CENTRAL INDIA

Shameem Khan, Sunil Kumar*, Sachin Agrawal, Shilpa Bawankule

ABSTRACT

Introduction: Poisoning with Organophosphorus compounds is an important global health problem, and is possibly the most common acute poisoning in the developing countries. Vidarbha in central India is home for approximately 3.4 million cotton farmers and 95% of these are struggling with the massive debt and so common mode of poisoning. This study was done to correlate the severity of acute organophosphorus poisoning with serum cholinesterase and serum creatine phosphokinase level, also to assess which one has better impact. Materials and Methods: A Prospective observational clinical study was done on 80 patients suspected of Organophosphorus poisoning of age >15 years admitted to emergency unit at a tertiary rural teaching healthcare centre of central India. Serum cholinesterase level and serum Creatine phosphokinase level was estimated at the time of admission in all patients and severity of Organophosphorus poisoning was assessed according to Peradenya Organophosphorous Poisoning (POP) Scale. Results: Among 80 enrolled patients 71.25% were male and 28.75% were females. The mean age of the patients were 33.52 (SD 11.62) with 43 (53.75%) in 15- 29 year group and 24 (30%) in 30-44 years groups. The severity of poisoning was directly correlated with serum cholinesterase level (p = 0.0001) and non significant with serum Creatine phosphokinase, (p =0.081). There was significant correlation between serum cholinesterase with outcome of the patients, p < 0.005, but there was no significant correlation between Creatine phosphokinase and outcome of the patients, p = 0.15. Conclusion: In our study severity as well as outcomes of op poisoning was directly correlated with serum cholinesterase level and non significant with serum Creatine phosphokinase.

Keywords: organophosphorus, poisoning, serum cholinesterase, serum Creatine phosphokinase, severity, correlation.