Abstract

MICROWAVE ASSISTED SYNTHESIS, CHARACTERISATION AND ANTI MICROBIAL ACTIVITIES OF FEW NICKEL (II)- THIOSEMICARBAZONES COMMPLEXES

Kamal Kishor Verma, Raja Ram, Khushbu Sharma and Narendar Bhojak*

ABSTRACT

A series of four novel Nickel(II) aryl thiosemicarbazones Complexes having the general Composition [Ni(L1)2Cl2], [Ni(L2)2Cl2], [Ni(L3)2Cl2] and [Ni(L4)2Cl2]{where L1= 4-Nitroacetophenone thiosemicarbazones (4NAT), L2 = 3-Nitrobenzaldehyde thiosemicarbazones (3NBT), L3 = 4-Hydroxybenzaldehyde thiosemicarbazone (4HBT) and L4 = 4-Aminoacetophenone thiosemicarbazone (4AAT)} have been synthesized by the reaction of thiosemicarbazide with substituted aromatic aldehydes and ketones by conventional heating as well as microwave irradiations method followed by complexation with Nickel(II) metal. The synthesized Compounds have been characterised by elemental analysis, melting point determination, FTIR, UV-visible spectral analysis. The synthesized ligands and their new metal Complexes have been screened in vitro for antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis bacteria.

Keywords: Thiosemicarbazones, Microwave irradiation, Nickel (II) complexes.