Abstract

FORMULATION AND EVALUATION OF ACECLOFENAC ORODISPERSIBLE TABLETS USING NATURAL DISINTEGRANT

*Harish R. Lukkad¹, Pravin K. Bhoyar², Jagdish R. Baheti¹, Nitin D. Somnathe³, Dhanashri B. Nagulwar⁴ , Prasad P. Kathade²

¹Shriman Suresh Dada Jain College of Pharmacy, Chandwad, Nasik, Maharashtra, India
²Siddhivinayak College of Pharmacy,Warora, Dist-Chandrapur, Maharashtra, India.
³Department of Pharmacy, Wadhawani College of Pharmacy, Yavatmal, Maharashtra, India.
⁴Department of Pharmaceutics, Sharad Pawar College of Pharmacy, Dist: Nagpur, Maharashtra, India.

ABSTRACT

Fast dissolving tablets are dissolved/disintegrate without water within few second to few minutes. Aceclofenac, a non-steroid anti inflammatory drug used for pain and inflammation and was selected as the model drug. Dispersible tablets of aceclofenac were prepared using natural substance mango peel pectin(MPP) as disintegrant in different concentration and also prepared using standard superdisintegrant crospovidone(CPD) by direct compression technique. The prepared powder blend was evaluated for various parameters like bulk density, tapped density, angle of repose, compressibility index and Hausner ratio. Formulations of MPP were evaluated for hardness, friability, wetting time, disintegration time, In vitro dissolution study and were compared with CPD. The study reveals that MPP can not be used as promising superdisintegrant, but due to its good solubility in biological fluid and better swelling index, it can be used to prepare fast dispersible tablets.

Keywords: Aceclofenac, Mango peel pectin, Crospovidone, Direct compression technique.