Abstract

A NOVEL APPROACH ON TRANSDERMAL DRUG DELIVERY SYSTEM [TDDS]

Pravin Chinchole*, Sagar Savale and Kamlesh Wadile

ABSTRACT

Transdermal Drug Delivery System is the system in which the delivery of the active ingredients of the drug occurs through the skin. Transdermal drug delivery system can improve the therapeutic efficacy and safety of the drugs because drug delivered through the skin at a predetermined and controlled rate. Skin is the important site of drug application for both the local and systemic effects. Skin of an average adult body covers a surface of approximately 2 m2 and receives about one-third of the blood circulating through the body. Skin is an effective medium from which absorption of the drug takes place and enters the circulatory system. Various types of Transdermal patches are used that delivered the specific dose of medication directly into the blood stream. This review article covers a brief outline of the Transdermal drug delivery system, advantages over conventional drug delivery system, Layers of the skin, various components of Transdermal patch, penetration enhancers, and evaluation of Transdermal system and applications of Transdermal patch.

Keywords: Metoprolol tartrate, Transdermal films, Invitro permeation studies, Evaluation of TDDS.