Abstract

THE USE OF CLINICAL PHARMACOKINETICS IN THE DESIGN AND CONTROL OF MEDICAL PRESCRIPTION

Gilberto Quiñonez Palacio* and Lizbeth Mariela Cerón Ramírez

ABSTRACT

The study was done in 14 patients hospitalized in Tijuana Baja California, State Hospital. Creatinine clearance and renal function were determined using the Crockfort-Gault nomogram. The halflife of gentamycin and dosage were obtained with the Fuller- Goldman method. This method presents an enormous advantage for calculating and obtaining doses which can be used to reach ideal plasmatic concentrations. This allowed us to readjust doses in an analytical way. Analyzing the data obtained of the plasmatic concentrations in a stationary state we found that 65% of the patients had serum concentrations that fell within recommended levels (2 – 4.9 mcg/ml) for the pathologies encounter in the study. In these cases the patients had a volume of distribution between 12 to 16.3L/Kg. This pharmacokinetic method is an excellent guide for the designing of individual regimen of dosification in a scientific way. Its predictive power is very acceptable for pharmacologic agents that have a very narrow therapeutical window. 35% of the cases did not reach plasmatic concentrations in stationary state because they presented an atypical pharmacokinetic parameter (obesity). Pharmacokinetics methods area beneficial for administrating pharmacologic doses in patients, they provide a scientific alternative to this procedure. Especially in pharmacologic agents that have a high potential for producing toxic side effects.

Keywords: Pharmacokinetics parameters, Fuller-Goldman Method, Crockfort-Gault nomogram.