AN EVALUATION OF THE GENOTOXICITY OF AZODYES BY USING INVIVO MICRONUCLEUS ASSAY
Vijaya Parthasarathy*, Mumtaj Peer Mohammed and Parimalam Boopathi
ABSTRACT
The frequency of micronucleated polychromatic erythrocytes and the
polychromatic to normochromatic erythrocytes ratio was studied in
Swiss albino mice treated with three azodyes; Direct Brown, Direct
Green, Direct Black (100 mg /Kg body weight) concentration, after
which significant toxicity to the erythroid compartment was observed.
The toxicity study of these Azodyes indicates to design new Azodyes
that are safe and yet maintain useful dye properties.
Keywords: Genotoxicity, Micronucleus Assay, Azodyes.
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