Abstract

FORMULATION AND EVALUATION OF HERBAL SYRUP USED IN THE MANAGEMENT OF CHOLESTEROL AND KIDNEY STONES

Dr. Prasobh G. R.*, Jacob Mathew, Ameena K., Abdul Vajid K., Prasanth Kumar M., Suryanarayanan J. and Dr. Sapna Shrikumar

ABSTRACT

Hypercholesterolemia is the presence of high levels of cholesterol in the blood and it is the major risk factor for coronary heart disease, a cause of heart attacks. Hypercholesterolemia is typically due to a combination of environmental and genetic factors. Kidney stone is the formation of stones in the urinary tract, causing pain and bleeding, and may lead to secondary infection. Of many types of stones that are formed, the most common are calcium oxalate. Urolithiasis (renal stone formation) is a recurrent disorder predominant in males. The present day medical management of urolithiasis is either costly or not without side effects. Hence, the search for antilithiatic drugs from natural sources has assumed greater importance and the prepared natural syrup playing a significant role in the management of kidney stones. Formulation and evaluation of herbal syrup and testing the syrup in animals by invivo manner. Syrup showed promising results in the size reduction of kidney stones by invivo method by ethylene induced urolithiasis in albino wistar rats (P Ë‚ 0.001). The treatment of lithiasis- induced rats by natural syrup also restored all the elevated biochemical parameters (creatinine, blood urea nitrogen and uric acid) restored the urine pH of normal and increased the urine volume significantly (P Ë‚ 0.001) when compared to the model control drug. Natural syrup showed prominent results in the management of renal calculi by invivo methodology. Studies in humans can further confirm and revalidate the use of these agents in real time clinical settings.

Keywords: Herbal syrup, Albino wistar rats, Phytotherapy.