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FORMULATION AND EVALUTION OF ACECLOFENAC SUSTAINED RELEASED TABLET
Sagar Kishor Savale*
ABSTRACT Aceclofenac is a Non-steroidal Anti Inflammatory drug (NSAIDS). It can shows Anti-inflammatory, Antipyretic, and analgesic activity and Aceclofenac is important to Inhibition of Cyclooxygenase (COX I, COX II) Enzyme is responsible for Inhibition of Prostaglandins Synthesis. The Authentication and Preformulation studies associated to pure drug Aceclofenac is conducted for maintaining their standard, quality, purity and stability.The formulation of Aceclofenac Sustained release Tablet is important to give prolonged activity in prolonged drug release in Extended Period of Time for the Long Term Therapeutic activity. The Formulation of Sustained Released Tablet by using Suitable Excipients such as(MCC, PVP K 30, I.P.A., HPMC K 4 M, HPMC K 15 M, Acrypol 934 P, Aerosil and Magnesium Stearate). This Aceclofenac Sustained released tablet is from by Wet Granulation Method. The Prepared sustained released Tablet is Evaluated In terms of bulk density, tapped density, angle of repose, carr’s Index and, hardness test, weight variation test, friability test and in vitro study. The result associated in Optimized batch is good to Satisfactory and having a good free flowing property. The hardness, weight variation, and friability these values are within the pharmacopeia limit. The in vitro Dissolution studies shows Maximum percentage of release of drug (96.18) with in end of 8 hours. Keywords: Non-steroidal Anti Inflammatory drug, Sustained Release, anti-inflammatory drug, extended release, prolonged released. [Download Article] [Download Certifiate] |