Abstract

COMPARATIVE STUDY OF SOLID LIPID NANOPARTICLE AND NANOSTRUCTURED LIPID CARRIER OF CARVEDILOL

Sanjay S. Jain*, Dr. Neha M. Dand, Dr. Kisan R. Jadhav, Dr. Vilasrao J. Kadam

ABSTRACT

objective of the present investigation was to develop solid lipid nanoparticles (SLN) & Nanostructured lipid carrier (NLC) of an antihypertensive drug carvedilol by high shear homogenization coupled with ultrasonication method. Lipid nanoparticles (LNP) were prepared by Glyceryl monostearate as solid lipid and Oleic acid as liquid lipid at various concentrations and tween 80 as surfactant at various concentrations as an attempt for improving its gastrointestinal uptake and oral bioavailability and also to sustain its release. The developed LNP were characterized for particle size, polydispersity index, entrapment efficiency of carvedilol and In vitro release. Optimization was done using 32 factorial design using Design Expert® 8.0.6 software. The mean particle size was found to be in the range of 40-260 nm with a narrow range of polydispersity index. The entrapment efficiency (EE %) of LNPs was more than 70% and increased as the concentration of lipid was increased and decreased as the concentration of surfactant was increased. In vitro release of carvedilol from NLC dispersion was found better as compared to SLN dispersion.

Keywords: Solid lipid nanoparticles; Nanostructured lipid carrier; carvedilol; Glyceryl monostearate; Oleic acid; Tween 80.