Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL MELT-IN-MOUTH OF LORAZEPAM FOR SUBLINGUAL USE

*Priya Vijaysingh Bais, Dr. Kanchan P. Upadhye and Gouri Dixit

ABSTRACT

1*Priya Vijaysingh Bais, 2Dr. Kanchan P. Upadhye and 3Gouri Dixit 1Research Scholar, 2Associate Professor, 3Asst. Professor, Priyadarshini J. L. College of Pharmacy, Electronic Zone Building, MIDC, Hingna Road, Nagpur-16. ABSTRACT The present study is an attempt to formulate and develop fast dissolving oral melt-in-mouth of Lorazepam by solvent casting method using pectin as a polymer for sublingual use. Solvent casting method was used for formulation of films where the required percentage of polymer solution was prepared by dispersing the polymer powder in distilled water with other excipients like plasticizer, sweetener, solvent etc separately with continuous stirring and then this solution was poured in the mould.The films prepared using pectin were evaluated for thickness, swelling index, tensile strength, % elongation, folding endurance, disintegration time and % drug release. Out of these films, C5 batch showed optimum performance against all other prepared formulations and was subjected to weight variation, thickness, tensile strength, % elongation, swelling index, folding endurance, surface pH, drug content, disintegration time, in-vitro dissolution % drug release, ex-vivo diffusion for % drug permeated and stability studies. Thus, fast dissolving film using water soluble polymer like pectin can be prepared using solvent casting method for a poorly water soluble drug such as Lorazepam.

Keywords: Fast dissolving oral melt-in-mouth, sublingual use, disintegration time.