Abstract

FORMULATION AND EVALUATION OF HERBAL GEL FROM DIFFERENT PARTS OF CYAMPOSIS TETRAGONOLOBA (L.) TAUB. FOR WOUND HEALING

Sumitra Singh* and Bhagwati Devi Rohilla

ABSTRACT

The hydrogels prepared from ethanol extracts of leaves and fruits of Cyamposis tetragonoloba (L.) Taub. were investigated for their healing effect on excision and incision wound surface on swiss albino mice. Different formulations were topically applied on the wound surface as a single dose. Percentage of wound contraction, period of complete epithilization of excision and tensile strength of incision wound and histological studies of granulation tissue were used to evaluate effect of wound healing. The activity was compared with that of the control and metrogel (1% w/w) as standard drug. Both the formulation showed a significantly higher rate of contraction and shorten epithilization period in both the test models. In excision model healing was 99% in gel containing 5% w/w fruit ethanol extract and 90% in gel containing 5% w/w leaf ethanol extract (p

Keywords: Excision wound model, Incision wound model, Cyamposis tetragonoloba (L.) Taub.