Abstract

EVALUATION OF BIOLOGICAL EFFECT OF PLATELET RICH FIBRIN ON THE POLIFIRATION AND OSTEOGENIC DIFFERENCIATION OF CULTURED HUMAN DENTAL PULP STEM CELL AN- IN VITRO STUDY

Dr. Akhilesh Tomar, Dr. Akanksha Bhatt*, Dr. Vandana Pant, Dr. A. B. Pant

ABSTRACT

The height and density of alveolar bone is maintained by equilibrium, regulated by local and systemic influences between bone formation and resorption.[2] Thus, during periodontal infection, the formation and resorption may lead to different defect on bony surface like, horizontal or vertical bone loss, osseous craters, ledges, exostoses etc. These defects need to be corrected or recontoured, which can be achieved by reconstructive bone surgeries using various graft materials or other procedures. Materials to be grafted can be obtained as autografts, allografts xenografts & alloplast. Graft materials should have the properties of biological acceptability, predictability, clinical feasibility, minimal operative hazards, minimal post-operative sequelae and patient acceptance.[3] Most of the bone grafts which are available till date has the limitation in either their their osteoconductive property or the predictability of clinical outcome.

Keywords: Platelet Rich Fibrin, Osteogen, Dental Pulp, Stem Cell, Osteoblasts.