Abstract

EMULGEL: AN ADVANCE TECHNIQUE FOR PENETRATION OF HYDROPHOBIC DRUGS

Hiba Harshan* and Krishnapillai M.

ABSTRACT

Gel has many advantages but their main limitation is that delivery of hydrophobic drugs across the membrane to overcome this combination of emulsion and gel and the dosage form is referred as EMULGEL. By this method hydrophobic moiety can enjoy the unique properties of gels. Hydrophobic drugs cannot directly incorporate into gel base because solubility acts as a barrier and causes problem during the release of drug. Emulgel formulation helps the hydrophobic drugs incorporation into the oil phase and then oily globules are dispersed in aqueous phase resulting in O/W emulsion which can mixed into gel base. Emulgel provide better stability and control release of drug with short half life. The use of emulgel is extended in analgesic and antifungal drugs.

Keywords: Hydrophobic drugs, Emulgel.