Abstract

EVALUATION OF IN VITRO ANTI ARTHRITIC ACTIVITY OF ACACIA AURICULIFORMIS A. CUNN. EX. BENTH. STEM BARK

Sumitra Singh* and Nidhi Sharma

ABSTRACT

The present study was aimed to evaluate in vitro anti arthritic activity of ethyl acetate, ethanol and aqueous bark extracts of Acacia auriculiformis A. Cunn. (Family: Mimosaceae). The ethyl acetate, ethanol and aqueous extracts of the plant were subjected to preliminary phytochemical screening. Denaturation was induced by incubating the extracts with bovine albumin under controlled experimental conditions. Protein denaturation was calculated by determination of their absorbance. The results showed that the plant extracts showed anti arthritic activity in a concentration dependent manner and the activity was increased on increasing the concentration of extracts. Ethanol extract was found to be more effective than the other extracts. The present study reveals that stem bark of Acacia auriculiformis possess anti arthritic activity. The activity may be due to presence of phenols, tannins, and flavonoids present in the plant.

Keywords: Anti arthritic activity, protein denaturation, Acacia auriculiformis.