Abstract

PHARMACOKINETICS OF CEFTRIAXONE IN NORMAL AND SALMONELLA TYPHIMURIM INFECTED GOATS

Mossad Gamal El-Din EL Sayed-Ashraf Abd El –Hakim El–Komy, Faten Ibrahim EL Sayed

ABSTRACT

The pharmacokinetic parameters of ceftriaxone in blood, urine and milk following intravenous and intramuscular (single & repeated) administrations were estimated in normal and experimentallySalmonella typhimurum infected goats. Following a single intravenous injection of 20 mg ceftriaxone/kg b.wt. in normal goats, ceftriaxone could be detected therapeutically for 8 hours post intravenous injection. The serum concentration – time curve of ceftriaxone following intravenous injection showed that the drug obeyed a two compartments open model. The intramuscular bioavailability of ceftriaxone in normal goats was 61.28%. Intramuscular injection of 20 mg ceftriaxone per kilogram body weight twice daily for five consecutive days in normal and Salmonella typhimurium infectedgoats revealed a lower significant serum ceftriaxone concentration after the first, third, fifth, seventh, ninth doses in Salmonella typhimurium infected goats compared with normal goats.. The high milk concentrations of ceftriaxone in lactating goats after repeated intramuscular administrations, suggested that ceftriaxone could be used for treatment of mastitis caused by Salmonella typhimurium and other sensitive microorganisms to ceftriaxone in lactating goats. The high concentrations of ceftriaxone in urine after repeated intramuscular administrations, suggested that ceftriaxone is a suitable antimicrobial for treatment of urinary tract infections caused by Salmonella typhimurium and other sensitive microorganisms to ceftriaxone in goats.

Keywords: Pharmacokinetics, ceftriaxone, goats.