Abstract

AN UPDATE REVIEW ON NOVEL ADVANCED OCULAR DRUG DELIVERY SYSTEM

*Rituraj Shivhare¹, Ashish Pathak¹, Nikhil Shrivastava², Chandraveer Singh¹, Gourav Tiwari¹, Rajkumar Goyal¹

¹Department of Pharmaceutics, ShriRam College of Pharmacy, S.R.G.O.C. Campus, AB Expressway Banmore, Morena, M.P., India.
²Department of Pharmacology, ShriRam College of Pharmacy, S.R.G.O.C. Campus, AB Expressway Banmore, Morena, M.P., India.

ABSTRACT

Eye is the most complicated and sophisticated organ of the body, so it is important that give the especial attention to the eye diseases. For eye diseases various drug delivery system are available but there are various limitation like rapid drainage, loss from tear flow, eye sensitivity due to protective anatomy and physiology of eye. Absorption and elimination of therapeutic active agents depend upon the physiochemical, microbiological and pharmaceutical properties of dosage form and also depend upon the eye anatomy and physiology. Problems which are associated with conventional ophthalmic dosage form may reduce with new drug delivery system. New drug delivery system improves the bioavailability, residence time, doctor and patient complies and reduces the toxic effect, systemic side effect, frequency of dosing and discomfort of patients. There are many new drug delivery systems available which are applied in the eye. In this review we are focusing on various new drug delivery system like inserts, contact lenses, mucoadhesive, collagen shield, penetration enhancers, implants, particulate and vasicular system like liposomes, niosomes, pharmacosomes, microemulsion, nanoparticles, iontophoresis, dendrimers and also on more recent advanced approaches like gene therapy, aptamers, protein and peptide therapy, oligonucliotide, siRNA, stem cell therapy and many more.

Keywords: rapid drainage, physiochemical, microbiological, pharmaceutical properties, new drug delivery system.