Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF 1-(4-(P-TOLUIDINO)-6-(4-CHLOROPHENYLAMINO)-1, 3, 5-TRIAZINE 2-YL) - 3-METHYL -2, 6- DIPHENYL PIPERIDINE-4-ONE.

P. R. Logesh Kumar* and Dr. S. Vijayakumar

ABSTRACT

Triazine is the chemical species of six-membered heterocyclic ring compound with three nitrogens replacing carbon-hydrogen units in the benzene ring structure. The names of the three isomers indicate which of the carbon- hydrogen units in the benzene ring position of the molecules have been replaced by nitrogens called 1,2,3-triazines. The triazine derivative of 1-(4-p-toludino)-6-(4-chlorophenylamino)-1, 3, 5-triazine-2-yl)-3-methyl-2, 6-diphenylpiperidine-4-one was synthesized by condensation method by using various amines. The final synthesized compound structure elucidated by spectral analysis and screened for antibacterial and antifungal activity using different strains of bacteria and fungi by turbidometric method at different concentration. Result showed marked anti-bacterial and anti-fungal activity with increasing the concentration and 250 μg revealed equal to standard drug ciprofloxacin in antibacterial activity.

Keywords: Triazine, Chlorophenyalmine, spectral analysis, anti-microbial and anti-fungal.