Abstract

FORMULATION AND EVALUATION FAST DSISSOLVING TABLETS OF NARTRIPTAN USING SUPER DISINTEGRANTS

L. Rajesh Patro*, C. Ramesh, D. Ravi, G. Nithin Kumar and K. Raghuvaran Reddy

ABSTRACT

Naratriptan hydrochloride is used for acute oral migraine therapy.In the present study an attempt was made to prepare oral fast dissolving tablets of Naratriptan hydrochloride with the dose of 2.5mg in order to improve the quick on set of action and patient compliance fast dissolving tablets of Naratriptan were prepared by using cross caremellose sodium, sodium starch glycollate cross povidone by direct compression method.study of the preformulation charcteristics and FTIR studies indicate that there was o interaction between Nartriptan and excipients used in the formulation .out of different formulae from (F1 – F12 ) F3 found to be optimized which showed a faster rate of drug release .stability studies were conducted for the optimized formulae found to be satisfactory. These findings suggest that the fast dissolving tablets of Nartriptan is considered to be potentially useful for treatment of migraine where quicker onset of action is desirable.

Keywords: Nartriptan,Fast Dissolving Tablets ,Superdisintegrants,Dissolution Profile.