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ANTIMUTAGENIC ACTIVITY OF ETHANOLIC EXTRACT OF CARALLUMA FIMBRIATA
S. Sasikala*, Dr. S. Gowri and M. Thiruselvi
ABSTRACT In the present investigation the potential activity of ethanolic extract of Caralluma fimbriata for its antimutagenicity using Salmonella typhimurium was determined. This is mainly based on the reversion of mutant cells by mutagenic agents. It was found that the extract inhibit the revertant formation produced by direct acting mutagens such as sodium azide, Ethidium bromide and Hydroxyl amine. The extracts showed more than 95% inhibition of mutagenicity at a concentration of 1mg/plate and the activity decreased with decreased concentration. It could also produce significant inhibition of mutagenicity and the results are highly significant. Keywords: Caralluma fimbriata, Salmonella typhimurium, antimutagenicity, Sodium azide, Ethidium bromide and Hydroxyl amine. [Download Article] [Download Certifiate] |