Abstract

PHYTOCHEMICAL PROFILING OF MANGOSTEEN FRUIT, GARCINIA MANGOSTANA

Manimekalai I., Sivakumari K*., Ashok K and Rajesh S.

ABSTRACT

The present study deals with phytochemical profiling of epicarp and endocarp extracts of mangosteen fruit, Garcinia mangostana. Fresh fruits were procured from market, identified and authenticated and methanol, chloroform, hexane and ethyl acetate extracts were prepared for both epicarp and endocarp of the fruit. The extracts were standardized against hepatocellular carcinoma (HeP-G2) cells and the extracts (Chloroform extract of epicarp and hexane extract of endocarp) showing best anti-proliferative activity was selected for qualitative and quantitative phytochemical screening. Qualitative analysis revealed the presence of phenols, flavonoids and triterpenoids in both the extracts, while the quantitative phytochemical analysis of HPLC and GC revealed that phenol content was higher in chloroform extract of epicarp than hexane extract of endocarp and flavonoids and triterpenoid content were higher in hexane extract of endocarp. The FT-IR spectrum was used to identify the functional group of the active components based on the peak value in the region of infrared radiation. Likewise, GCMS spectral analysis showed 160 aromatic compounds in epicarp and 105 compounds in endocarp. The results are discussed in the light of previous literature.

Keywords: Garcinia mangostana, phytochemical profiling, epicarp and endocarp.