Abstract

CHRONIC ADMINISTRATION OF OLANZAPINE (AN ANTIDEPRESSANT DRUG) LEADS TO IMPAIRED GLUCOSE TOLERANCE IN MICE

Farjana Akther Noor, Mohammad Najmul Hossain and Mohammed Rahmatullah*

ABSTRACT

Background. Olanzapine is a prescription drug used for treatment of psychotic mental disorders. Some reports have indicated diabetes risk following chronic administration of olanzapine. It was of interest to see whether chronic olanzapine treatment leads to impaired glucose tolerance in mice. Methods. Impairment of glucose tolerance was determined through oral glucose tolerance tests (OGTT) in mice. Results. Oral administration of olanzapine to mice at a dose level of 100 mg olanzapine per kg body weight led to statistically significant elevations in blood glucose levels compared to control animals (without olanzapine) following OGTT. After 1, 2 and 4 weeks of olanzapine administration, in oral glucose tolerance tests, the elevations in blood glucose in glucose-challenged mice were, respectively, 119.8, 161.1, and 166.4% compared to control mice (100.0%). Conclusion. Chronic administration of olanzapine can cause impaired glucose tolerance, which can serve as a model to explore other medications to alleviate the problem.

Keywords: Olanzapine, Bangladesh, glucose, OGTT.