Abstract

A SHORT REVIEW ON ORAL FAST DISSOLVING FILM CONTAINING CEFPODOXIME PROXETIL NANOPARTICLE

Chandra Kala Singh*, Vishnu Tiwari, Ravi Shankar, Chandra Prakash Mishra, Sarvesh Jain, Sandeep Jain and Sandhya Jaiswal

ABSTRACT

Development of poorly soluble and permeable drug molecules using nanoparticles formulations has proven to be highly successful due to the greater surface, resulting in improvements in dissolution and bioavailability as well as enhanced permeability. Cefpodoxime proxetil (CP), a drug candidate belonging to BCS class IV with poor solubility and poor permeability having limited oral bioavailability is an orally administered, extended spectrum, semi-synthetic β- lactum antibiotic of cephalosporin class. To enhance the oral bioavailability of BCS class IV drug, nanoparticles were used as a carrier. Oral disintegrating films (ODFs) are the most eminent drug delivery system among pediatrics and geriatrics. These films are designed to dissolve upon contact with a wet surface, such as the tongue, within a few seconds and the drug is directly absorbed into systemic circulation, degradation in gastrointestinal tract and first pass effect can be avoided leading to increased bioavailability. Fast disintegrating films have superiority over fast disintegrating tablets as the latter are associated with the risks of choking and friability. Various approaches are employed for formulating ODFs among which solvent casting and spraying methods are frequently used. So, it is concluded that nanoparticles loaded oral disintegrating films be able to improve the oral bioavailability compared to conventional system.

Keywords: Nanoparticles, Permeability, Bioavailability, Solubility, Dissolution.