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FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING POLYHERBAL TABLETS ON BRONCHITIS
Anil Tatiya*, G. P. Pathak, Sanjay Surana and Dhanraj Mahajan
ABSTRACT
Most of the ayurvedic formulations are polyherbal. Compared to powder dosage forms, tablets have advantages with respect to dose uniformity, patient compliance and less chances of adulteration. Polyherbal fast dissolving tablets (FDTs) were formulated and prepared by wet granulation technique to increase patient compliance for treatment of bronchitis. Micro-crystalline cellulose was used as super-disintegrant. Tablets were evaluated for hardness, weight variation, friability, wetting time, disintegration time and in vitro dissolution test. The compatibility of drug excipient was evaluated by FT-IR study. It was observed that increasing concentration micro-crystalline cellulose from 42.33 mg per tablet to 44.43 mg per tablet reduces disintegration time from 16 min to 11min 25 sec. Two of the prepared formulation without micro-crystalline cellulose had disintegration time of 18 min 20 sec and17 min 34 sec respectively. Marketed formulation Lavangadi vati had disintegration time of 18 min 50 sec. FTIR study of only drug and drug with excipient were comparable, which showed that there was no interaction between drug and excipient. Based on the results, it was concluded that the prepared tablets containing Micro-crystalline cellulose exhibited better and faster drug dissolution than marketed tablets (Lavangadi vati). Keywords: Polyherbal formulation, fast dissolving tablets, Micro-crystalline cellulose, FTIR. [Download Article] [Download Certifiate] |