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DETERMINATION OF THE PHYTOCHEMICAL CONSTITUENTS, ANTIMICROBIAL AND ANTITUSSIVE ACTIVITIES OF THE LEAVES OF SOLANUM TORVUM SWARTZ
Abena Amponsaa Brobbey*, Anna Kwarley Quartey, Samuel Otuo-Serebour, Isaac Ayensu
ABSTRACT
Various parts of Solanum torvum of the solanaceae family have demonstrated valuable medicinal properties including the treatment of cough and other fungal and bacterial infections. In this study, the phytochemical constituents, the antimicrobial and the antitussive activities of the methanolic extract of the leaves of Solanum torvum have been determined. The phytochemical screening identified the following phytoconstituents; tannins, flavonoids, reducing sugars, saponin glycosides, alkaloids, phytosteroids and terpenoids. The antimicrobial assay was performed on Staphylococcus aureus, streptococcus pyogenens, klebsiella pneumonia and Escherichia coli using agar well diffusion method that gave minimum inhibitory concentrations of 2.5 mg/ml, 3.16 mg/ml, 5.0 mg/ml and 5.0 mg/ml respectively. The Antitussive assay was carried out on un-anaesthetized guinea pigs of weight 250-490 g in five (5) groups of four (4) exposed to nebulized aqueous solution of citric acid to obtain a basal response to the citric acid. Groups 1 and 2 were administered Keywords: Solanum torvum, Antitussive, Antimicrobial, Citric acid. [Download Article] [Download Certifiate] |