Abstract

ORAL GLUCOSE TOLERANCE TESTS IN MICE WITH A POLYHERBAL FORMULATION DIABETO-MLF

S.M. Shatil Shahriar and Mohammed Rahmatullah*

ABSTRACT

Background. Diabetes is a serious disease leading often to fatal conclusions. The disease and its related complications are fast becoming major health concerns among the population throughout the world. The objective of this study was to evaluate the antihyperglycemic activity of a polyherbal formulation, Diabeto-MLF. Methods. Oral glucose tolerance test (OGTT) was used to determine antihyperglycemic activity of Diabeto-MLF, which consisted of methanol extract of leaves of Malva verticillata, and seeds of Lathyrus sativus and Foeniculum vulgare in a 1:1:1 (w/w/w) ratio. Results. Administration of Diabeto-MLF led to dose-dependent reductions in blood glucose levels in glucose-loaded mice. At doses of 100, 200 and 400 mg per kg body weight, the extract reduced blood glucose levels by 36.3, 39.2, and 40.8%, respectively compared to control animals. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 47.1%. Conclusion. The results suggest that Diabeto-MLF can be used as a potential drug to reduce blood glucose levels in diabetic patients.

Keywords: Antihyperglycemic, Malva verticillata, Lathyrus sativus, Foeniculum vulgare