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BIOLOGICAL ACTIVITIES OF CRUDE EXTRACTS FROM PENICILLIUM WAKSMANII ISOLATED FROM MOSQUITOES VECTORS OF TROPICAL DISEASES
Jacqueline Santos Cruz,*, Gisela Lara da Costa and José Daniel Figueroa Villar
ABSTRACT Considering that Penicillium genus are capable to produce a diversity of secondary metabolites, this work describes the production of bioactive metabolites from Penicillium waksmanii Zalessky, using fifteen strains isolated from mosquitoes vectors of tropical diseases. Strains were fermented in malt extract for seven days and extracted with ethyl acetate. All extracts were tested against bacteria and yeast, being active for at least one microorganisms used. Chemical and biological investigation on the ethyl acetate extract of this strain resulted in the isolation of two compounds identified by NRM technique: citrinin and 2-(4-butyl-phenyl)-ethanol. Keywords: Penicillium waksmanii, biological activity, secondary metabolites, mosquitoes. [Download Article] [Download Certifiate] |