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FORMULATION & DEVELOPMENT PANTOPRAZOLE LOADED MICROSPONGES FOR MANAGEMENT OF GERD
Ankit Agarwal*, Tripti Shukla, Neha Jain, Neeraj Upmanyu, SharadPrakash Pandey, Vinod Dhote
ABSTRACT
The aim of the present research is to develop multiple unit dosage form as microsponge of a drug meant for management of gastroesophageal reflux disease (GERD) using pantoprazole sodium. Microsponge containing pantoprazole sodium as active pharmaceutical ingredient with varying concentration of polymer (Eudragit RS 100), emulsifier (Poly vinyl alcohol) were obtained successfully using Quasi-emulsion solvent diffusion method. These formulations were studied for particle size and physical characterization. Scanning electron microscopy (SEM) images showed the microsponges porous and spherical in shape. The physical characterization showed that microsponge Keywords: Gastroesophageal reflux disease, Pantoprazolee, Poly vinyl alcohol, Eudragit RS 100, Quasi-emulsion solvent diffusion, scanning electron microscopy. [Download Article] [Download Certifiate] |