Abstract

ANALGESIC ACTIVITY OF SWERTIA CHIRAYITA

Neetu Sharma¹, Savita G. Aggarwal*², R. P. Kala³, Arun Kumar⁴

¹ Faculty, Department of Chemistry, Graphic Era University, Dehradun.

² Head, Department of Pharma Chemistry, Uttaranchal College of Technology & BiomedicalSciences, Dehradun.

³Head, Department of Chemistry, Uttaranchal College of Technology & BiomedicalSciences, Dehradun.

⁴Faculty, Pharma Division, SGRRITS, Dehradun, India.

ABSTRACT

Since the dawn of civilization, human being is dependant on higher plant species for their foods, clothing, shelter and health care need. The plant species were the main part of folk medicine practiced by the ancient peoples in different parts of the world, which include India, China, Middle East, Africa and South America. In India the earliest use of plant in medicine can be traced in Rig veda. The present study was designed to evaluate the analgesic of the methanol extract of whole plant of Swertia chirayita (Roxb. ex Fleming) H. Karst (Family Gentianaceae) in young albino mice and wistar rats. The analgesic activity was determined by using Hotplate and Tail flick methods. The crude extract was used in two doses as 100 mg/kg and 200 mg/kg and Nimusulide was used as the standard drug. The finding reveals that methanolic extract of Swertia chirayita possesses analgesic activity.

Keywords: Analgesic, Swertia chirayita, Nimusulide, Eddy’s hot plate, Analgesiometer.