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DENOSUMAB-A NEW THERAPEUTIC OPTION FOR OSTEOPOROSIS
*Dr. Sapna Patil
ABSTRACT Osteoporosis is a multifactorial progressive skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, predisposing it to increased fracture risk.[1] The capacity of bone to resist mechanical forces and fractures depends not only on the quantity of bone tissue but also on its quality.[2] Osteoporosis is called a "silent disease" because it progresses without symptoms until a fracture occurs. Because of larger skeletons and no period of rapid hormonal change osteoporosis progresses more slowly in men than in women.[3] The fractures caused by osteoporosis have a great impact on public health, as they are often associated with increased morbidity, mortality and high economic cost. Thus, in the last two decades pharmacological and non-pharmacological treatment (usually based on physical exercise) options have been largely developed to reduce the risk of fractures in osteoporotic patients. Keywords: . [Download Article] [Download Certifiate] |