Abstract

DESIGN AND EVALUATION OF GASTRIC FLOATING MATRIX TABLETS OF AN ANTI-HYPERTENSIVE DRUG PERINDROPIL ERBUMINE

Neeraj Kumar Fuloria*¹, Swati Thosare², Shivkanya Fuloria², Kaveti Balaji¹, Sokkalingan Arumugam Dhanaraj¹

¹Department of Pharmaceutical Chemistry, Faculty of Pharmacy, AIMST University,Semeling Campus, Jalan Bedong-SemlingBedong, Kedah Darul AmanMalaysia 08100.

²Anuradha college of pharmacy, Amravati Universtiy, Chikhli, Dist Buldana India 440302.

ABSTRACT

The purpose of the present study was to prepare gastro retentive drug delivery system of Perindropil Erbumine by direct compression method. Nine formulations (F1-F9) of Perindropil Erbumine tablets were prepared by using various grades of Hydroxylpropylmethyl cellulose i.e., HPMC K4M, HPMC K15M. Sodium bicarbonate and citric acid was incorporated as a gas generating agents. Perindropil Erbumine floating matrix tablets were evaluated in terms of their physico-chemical parameter like weigh variation, friability, hardness, drug content, floating lag time and total floating time. The buoyancy lag time was found less than 1 minute for all the prepared tablets and affected by viscosity of the polymers and their concentrations. The total floating time for different formulations was in the range of 12-14 hours. The present work concludes that, floating tablets of Perindropil Erbumine showed promising result and there exist a scope for in vivo evaluation using suitable animal model.

Keywords: Perindropil Erbumine; HPMC; Floating tablets; Direct compression; Buoyancy; Swelling; In vitro release.