Abstract

FORMULATION AND EVALUATION OF SUSTAIN RELEASE MATRIX TABLETS OF AN ANTI-HYPERTENSIVE DRUG USING VARIOUS CROSS-LINKING AGENT

Guru Datta S*, Senthil Kumar, Mohammed Gulzar Ahmed and Ankit Acharya

ABSTRACT

The main aim of present work was to formulate and evaluate sustain release matrix tablets of Valsartan, an angiotensin II Receptor type 1 antagonist. Sustain release formulation are those which delivers the drug locally or systemically at a predetermined rate for a fixed period of time. The matrix table was prepared by direct compression method using by various concentration of chitosan and sodium alginate with combination of various release retardant polymer. The powder mixtures were subjected to various pre-compression and post compression parameters. In-vitro dissolution studies were carried out for 24 hours using 0.1 N HCL for first 2 hours and pH 6.8 phosphate buffer for 24 hours and the result indicates that formulations F4 and F7 showed good dissolution profile compare to other formulations. The compatibility of the drug, polymers and other excipients were determined by FT-IR Spectroscopy. Results showed that the drug was compatible with polymers and other excipients. The release data was fitted to various mathematical models such as Zero-order, First-order, Higuchi equation and Korsmeyer-Peppas model to evaluate the kinetics and the drug release. The drug release followed first order and the mechanism was found to be non-Fickian. The stability studies were carried out for 3 months and result indicates that the selected formulations (F4 and F7) were physiochemically stable throughout its study period. In conclusion, formulation containing higher concentration of chitosan and sodium alginate along with release retardant polymers sustained the drug release for the period of 24 hours.

Keywords: Carbopol 934P, Chitosan, sodium alginate, sustain release matrix tablet, Valsartan.