Abstract

CARDIOPROTECTIVE EFFECT OF TERMINALIA CHEBULA IN TYPE II DIABETES INDUCED CARDIOMYOPATHY IN RATS

Raman Sharma*, B P Srinivasan and Kiran Dubey

ABSTRACT

Objective: To investigate the ability of aqueous extract of the fruit of Terminalia chebula for cardio protection in STZ-induced diabetic rats. Method: Type II diabetes mellitus was induced by injection of Streptozotocin (90 mg/kg i.p.), in two days old neonates, after six weeks on confirmation of diabetes by fasting blood glucose level >160 mg/dl, once daily treatment of Terminalia chebula (200 mg/kg; orally) and Glimepiride (0.5 mg/kg/day;orally) was given for eight weeks. Results: Compared to diabetic group, the eight week treatment of Terminalia chebula and Glimepiride, significantly decreased blood glucose, glycated hemoglobin, cardiac hypertrophic index, MDA TGF-β1, TNFα, blood pressure, LDH, CK-MB, BNP, Caspase-3 while plasma insulin, body weight and SOD were found to be significantly increased. Conclusions: The result of the present study support the use of the Terminalia chebula fruits in diabetes induced cardiac damage.

Keywords: Terminalia chebula, diabetic cardiomyopathy, LDH, CK-MB, BNP, Caspase-3.