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PHARMACOKINETICS AND TISSUE RESIDUES OF CEFQUINOME IN NORMAL AND SALMONELLA ENTRETIDIS INFECTED CHICKENS
Mossad Gamal El-Din El Sayed, Ashraf Abd El-Hakem El-Komy, Elham Ahmed Mobarez, Ahmed Mohamed El-Mahdy*
ABSTRACT
The pharmacokinetics of cefquinome was studied following intravenous and intramuscular (single & repeated) injection. Cefquinome was assayed by High performance liquid chromatography method Following a single intravenous injection of 2 mg/kg body weight of cefquinome in normal chickens, plasma concentration-time curve was best described by a three compartments model with elimination half-life (t0.5(β) = 0.712 hour), volume of distribution (Vdss=389.23 ml/kg) and total clearance of the drug (Cltot= 0.048 ml/kg/min). Following a single intramuscular administration of 2 mg/kg body weight cefquinome in normal chickens, the peak plasma concentration (Cmax) was 3.53 μg/ml was achieved at a maximum time (Tmax) of 2.80 hour. The mean systemic bioavailability was 94.52 %. Keywords: Pharmacokinetics, cefquinome, tissue residues, chickens. [Download Article] [Download Certifiate] |