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Citation | 5450 | 3969 |
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SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL PYRIDAZINE BASED 1, 3, 4- OXADIAZOLES AS POTENTIAL ANTIMICROBIAL AGENTS
Hemalatha Gadegoni*, Sarangapani Manda, Shivaprasad Rangu
ABSTRACT Various 3-(5-methyl substituted sulfanyl-[1,3,4]oxadiazole-2-yl)- pyridazine derivatives (5a-e) have been synthesized from 5-pyridazine- 3-yl-3H-[1,3,4]oxadiazole-2-thione (4) by suing pyridazine-3- carboxylic acid (1) as starting material. The structures of these compounds have been established by IR, 1H-NMR and Mass spectral data analysis. The newly synthesized compounds were screened for their ability towards antibacterial, antifungal and nematicidal activities. Keywords: Pyridazine, 1,3,4-Oxadiazole, Antimicrobial activity, Nematicidal activity. [Download Article] [Download Certifiate] |